CISUC

OralCard: A bioinformatic tool for the study of oral proteome

Authors

Joel P. Arrais
Edar D Coelho
José Luís Oliveira
nuno rosa
Maria Correia

Abstract

Objectives
The molecular complexity of the human oral cavity can only be clarified through identification of components that participate within it. However current proteomic techniques produce high volumes of information that are dispersed over several online databases. Collecting all of this data and using an integrative approach capable of identifying unknown associations is still an unsolved problem. This is the main motivation for this work.

Results
We present the online bioinformatic tool OralCard, which comprises results from 55 manually curated articles reflecting the oral molecular ecosystem (OralPhysiOme). It comprises experimental information available from the oral proteome both of human (OralOme) and microbial origin (MicroOralOme) structured in protein, disease and organism.

Conclusions
This tool is a key resource for researchers to understand the molecular foundations implicated in biology and disease mechanisms of the oral cavity. The usefulness of this tool is illustrated with the analysis of the oral proteome associated with diabetes melitus type 2. OralCard is available at http://bioinformatics.ua.pt/oralcard.

Subject

Bioinformatics

Journal

Archives of Oral Biology, Vol. 58, #7, pp. 762-772, February 2013

DOI


Cited by

Year 2016 : 4 citations

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Year 2015 : 7 citations

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Year 2014 : 11 citations

 Coelho, Edgar D., et al. "Computational prediction of the human-microbial oral interactome." BMC systems biology 8.1 (2014): 24.

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 Moreira, Patrícia Maria Iria. Os microorganismos orais e o oraloma da diabetes tipo 2. Diss. 2013.

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Year 2013 : 4 citations

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 Brás, Vítor Daniel Moreira. O oraloma da diabetes melitos tipo 1 vs diabetes melitos tipo 2-um estudo comparativo. Diss. 2013.

 Moreira, Patrícia Maria Iria. Os microorganismos orais e o oraloma da diabetes tipo 2. Diss. 2013.

 Barbosa, Fernanda Correia, Joel P. Arrais, and José Luís Oliveira. "Quantitative Characterization of Protein Networks of the Oral Cavity." 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Springer International Publishing, 2013.